Antihyperlipidemic activity of Sphaeranthus indicus on atherogenic diet induced hyperlipidemia in rats. Treatment with both atorvastatin and Tc significantly reduced the increase in body weight as compared to the HFHS control group.
Management of primary hyperlipidemia.
The fundamental aspect in the etiology of these disorders is IR, which is linked to a wide array of other complications including hyperlipidemia. High fructose consumption increases the likelihood of weight gain and reduces circulating leptin concentration leading to IR associated with hyperinsuliemia, hypertriglyceridemia and hyperglycemia.
After 24 h, all the animals were given a known quantity 10 g of feed. Treatment with test drugs decreased blood sugar, insulin, lipid parameters, increased gastric emptying rate, decreased MDA levels, and catalase activity when compared to HFHS diet group, confirming the efficacy of the model.
The authentication report and certificate of analysis is available on file. Published online May 9. Higher HDL levels are documented to be physiologically beneficial.
At the end of the experiment, all the animals were taken group wise and blood was collected using the retro-orbital technique on day 0, 21, and Very low density lipoproteins without coronary atherosclerosis. The administration of sesamin improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein-B, oxidized-low-density lipoprotein, and serum creatinine levels in hyperlipidemic rats, while it increased the high-density lipoprotein cholesterol and apolipoprotein-A levels.
In recent years, in addition to its antibacterial effect [ 2 — 5 ], this natural compound has been increasingly studied for its effects against various diseases, including hyperlipidemia [ 6 ], diabetes [ 78 ], and nervous system [ 9 ] and cardiovascular diseases [ 10 — 12 ].
Specimens were then cleared in xylol, embedded in paraffin, sectioned at microns thickness and stained with hemtoxylin and eosin stain for examination described by Carleton. Havel RJ, Rapaport E. Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidney tissues were measured.
Author information: ADIS Press; Catalase activity was measured by the method of Aebi. Animals received standard pellet diet and purified water for 24 h over a period of 6 weeks and was considered as normal control NC group.
We also planned to confirm the efficacy of the model using two standard drugs, atorvastatin, a known antihyperlipidemic drug and pioglitazone, a known insulin sensitizer.
Hypolipidemic effects of Teucrium polium in rats. Experimental Animals Wistar rats of either sex aged 12 weeks g were used in the study. Background Berberine BBR is a medicinal alkaloid that is isolated from Coptis chinensis and has been used orally for decades in China as a safe over-the-counter OTC drug to treat diarrhea [ 1 ].
Oxidative stress also occurs as a result of decreased antioxidant defenses and has been related to the pathogenesis of atherosclerosis, and diabetes mellitus.
Transplanted hearts lasted in four groups of mice as follows: The hamsters were anesthetized for the collection of bile and liver samples. Berliner JA, Suzuki Y. Atorvastatin 2. This is the canonical understanding of organ rejection. References 1.
The fixed specimens were then trimmed, washed. This study confirms the development of a diet based cost-effective and time efficient experimental model, which can be used to study two important markers of cardiovascular disease that is, hyperlipidemia and IR and to explore the efficacy of new molecules in CHD.
CA, USA. After the 1 week adaptation period, the animals were used for the study. Abstract Objectives: TBA in bile, liver and feces The concentration of TBA in bile, liver and feces was determined at the end of the treatment using enzymatic kits.
High Fat Diet Induce Hyperlipidemia Incidences With Sever Changes in Liver Tissue of Male Albino Rats: A Histological and Biochemical Study. Jasem Hannon Hashim Al-Awadi 1, Karem Hammed Rashid 2, Alaa Jawad Hassen 3.
The objective of this study is to develop an experimental model of hyperlipidemia and insulin resistance (IR), markers of coronary heart disease (CHD) using high fat and high sugar (HFHS) diet and to evaluate the efficacy of the model using atorvastatin, a known antihyperlipidemic drug, pioglitazone, a known insulin sensitizer, and Tinospora cordifolia (Tc), an antidiabetic lawsonforstatesenate.comon: Rockville Pike, Bethesda, MD.
Induction of hyperlipidemia. Sprague-Dawley male rats with an average body weight of g were made hyperlipidemic by giving high-fat diet (HFD) obtained from National Institute of Nutrition, Hyderabad, for 15 lawsonforstatesenate.comon: Rockville Pike, Bethesda, MD.
· Methods. Golden hamsters were fed a high-fat diet (HFD) for 6 weeks to induce hyperlipidemia, followed by oral treatment with 50 and mg/kg/day of BBR or 10 and 30 mg/kg/day of lovastatin for 10 days, lawsonforstatesenate.com by: